Real Life Vampire? Anti-aging Influencer Bryan Johnson Swaps Out His Plasma in New Experiment—Here’s What He Says Happened

Tech millionaire and anti-aging enthusiast Bryan Johnson has once again shocked the internet with his latest biohacking venture. In a bold move to push the boundaries of longevity science, the 46-year-old revealed on Instagram that he recently had all of the plasma in his body removed—and replaced it with albumin, a major protein found in blood plasma.

This isn’t the first time the fitness influencer has made headlines for his radical health interventions. Known for investing millions annually in what he calls “Project Blueprint”—a quest to slow or even reverse biological aging—Johnson previously underwent a controversial transfusion using blood donated by his teenage son. Now, he’s taken that idea even further.

“I removed all the plasma from my body,” Johnson declared in a recent post. “The doctor said it’s the cleanest she’s ever seen.”

According to Johnson, this marks the second phase in his ongoing self-experimentation to reprogram his body to function like that of an 18-year-old. The first phase involved receiving plasma from his then-17-year-old son, a move that drew significant attention—and skepticism—from scientists and the public alike.

The current phase, however, bypasses donor blood altogether. Instead, Johnson’s medical team removed his own plasma and replaced it with a purified solution rich in albumin. He explained that the process is designed to flush out harmful substances the body struggles to eliminate on its own.

“Our bodies naturally remove waste,” he said. “But in today’s world, with the kinds of toxins we’re exposed to, sometimes the system needs help.”

The entrepreneur said he didn’t notice any immediate physical changes after the procedure. “I felt the same,” he shared. “Slept the same. Everything was normal.” But, he emphasized, this experiment isn’t about instant results—it’s about collecting data over time.

“We’re tracking dozens of biomarkers. We’ll look at the before and after and then assess what it’s doing for me.”

Public Reaction: Admiration and Criticism

As expected, reactions online were mixed. Some praised Johnson’s willingness to use his resources to explore new frontiers in human health.

“Say what you want, but this guy is pushing science forward,” wrote one supporter.
“At least he’s spending his money to test things on himself, not just talking about it,” another added.

Others, however, found the whole process excessive, even absurd.

“Just eat a burger, man,” one commenter joked. “You’re trying so hard to live longer, but are you really living?”

Another critic chimed in with: “He’s obsessed with not dying, but I wonder if he’s enjoying being alive.”

Inside Project Blueprint

Johnson’s life today is built around staying young. He reportedly spends over $2 million a year on diagnostics, supplements, therapies, and an intense daily routine. That includes strict control over his meals (which are weighed and planned down to the last calorie), sleep schedules, and exercise regimens. Every biological metric is monitored, from his heart health and liver enzymes to the elasticity of his skin.

His ultimate goal? To reduce his biological age—essentially making his body function as if it were decades younger than his actual age.

Despite the skepticism, Johnson remains committed. He has said he views his body as a data machine, and each experiment, whether it “works” or not, is a contribution to understanding how we might slow down human aging.

“I’m not trying to live forever,” he has said in previous interviews. “I just want to make 100 the new 40.”

Time will tell whether these plasma swaps yield meaningful results. But for now, one thing’s clear: Bryan Johnson isn’t afraid to push the boundaries of what it means to age—or not age—at all.